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Scientific publications


  1. Pignata, S. et al. A phase I-II study of elacytarabine (CP-4055) in the treatment of patients with ovarian cancer resistant or refractory to platinum therapy. Cancer Chemother Pharmacol (2011) 68:1347–1353
  2. Rizzieri D.A. et al. A Phase II Study of Elacytarabine/Idarubicin As Second Course Remission-Induction in Patients with Acute Myeloid Leukemia Who Failed Cytarabine/Anthracycline, and Evaluation of the Impact of the Nucleoside Transporter hENT1 on Response. Blood (ASH Annual Meeting Abstracts), Nov 2011; 118: 533
  3. Adema A.D. et al.: Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126. Invest New Drugs 2011, Oct. 15 (Epub)
  4. O'Brien S et al.: A Phase II Multicentre Study with Elacytarabine in Late Stage Acute Myeloid Leukaemia. European Hematology Association (EHA), 2010.
  5. Bergman A.M. et al.: Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models. Invest New Drugs. 2010 Jan 12
  6. Adema A.D. et al.: Induction of resistance to the lipophilic cytarabine prodrug elacytarabine (CP-4055) in CEM leukemic cells.Nucleosides Nucleotides Nucleic Acids. 2010 Jun;29(4-6):394-9
  7. A. Hendlisz et al.: Phase I study of oral CP-4126, a gemcitabine analog, in patients with advanced solid tumors. J Clin Oncol 28, 2010 (suppl; abstr e13078)
  8. Brueckner B et al.: Delivery of 5-azacytidine to human cancer cells by elaidic acid esterification increases therapeutic drug efficacy. Mol Cancer Ther. 2010 May;9(5):1256-64
  9. O'Brien, S. et al.: A Phase II Multicentre Study with Elacytarabine as Second Salvage Therapy in Patients with AML. Blood, Nov. 2009; 114:1042
  10. Adema, A.D. et al.:  Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel. Int J Oncol. 2010 Jan;36(1)285-294
  11. Andersson R et al.: Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions. Scand J Gastroenterol. 2009;44(7): 782-6
  12. Adema, AD et al.: Innovations and Opportunities to Improve Conventional (Deoxy)Nucleoside and Fluoropyrimidine Analogs in Cancer. Curr Med Chem. 2009; 16(35):4632-43
  13. Dueland, S. et al.: Intravenous administration of CP-4055 (ELACYTTM) in patients with solid tumours. A phase I study. Acta Oncologica, 2009; 48: 137-145 
  14. Galmarini, C.M. et al.: CP-4055 and CP-4126 are active in ara-C and gemcitabineresistant lymphoma cell lines. British Journal of Haematology. Volume 144 Issue 2, November 2008.
  15. Adams, D.J. et al.: Anti proliferative activity of ELACYTTM (CP-4055) in combination with cloretazine (VNP40101M), idarubicin, gemcitabine, irinotecan and topotecan in human leukemia and lymphoma cells. Leukemia & Lymphoma, April 2008;49(4): 786-797.
  16. Bruheim, S. et al.:  Antitumor activity of CP-4055 is enhanced in combination with bevacizumab, cetuximab and trastuzumab in human NSCLC xenografts. AACR-EORTC-NCI. 2007.
  17. Bergman, A.M. et.al.: Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinofuranosylcytosine in leukemia and solid tumor cell lines. Biochemical Pharmacology 67 (2004) 503 - 511.
  18. Bergman, AM et al.: Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukemia and solid tumor cell lines. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23 (8-9):1523-6.
  19. Bergman, AM et al.: Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1329-33.
  20. Andrei, G. et al.: Antiviral activity of ganciclovir elaidic acid ester against herpes virus.  Antiviral Research 45 (2000) 157-167.
  21. Breistøl, K. et al.: Antitumor Activity of P-4055 (Elaidic Acid-cytarabine) Compared to Cytarabine in Metastatic and s.c. Human Tumor Xenograft Models.  Cancer Research 59, 2944-2949, June 15, 1999
  22. Peters, GJ et al.: Cell specific cytotoxicity and structure-activity relationship of lipophilic. 1-B-D-arabinofuranosylcytosine (ara-C) derivatives. Nucleosides Nucleotides. 1999 Apr-May;18 (4-5):877-8.
  23. Jennings, R. et al.: Evaluation of a Novel, Anti-herpes Simplex Virus Compound, Aciclovir Elaidate (P-4010), in the Female Guinea Pig Model of Genital Herpes.  Antimicrobial Agents and Chemotherapy, Jan. 1999, p. 53-61
  24. Balzarini, J. et al.: Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.  Gene Therapy (1998) 5, 419-426